{"id":138066,"date":"2019-11-26T23:52:58","date_gmt":"2019-11-26T20:52:58","guid":{"rendered":"https:\/\/www.dailymail.co.uk\/health\/article-7725091\/IVF-increases-babys-risk-genetic-changes-11-FOLD-mothers-age-no-impact.html?ns_mchannel=rss&ito=1490&ns_campaign=1490"},"modified":"2019-11-26T23:52:58","modified_gmt":"2019-11-26T20:52:58","slug":"ivf-increases-a-babys-risk-of-genetic-changes-11-fold-and-a-mothers-age-has-no-impact","status":"publish","type":"post","link":"http:\/\/wardoon.net\/so\/ivf-increases-a-babys-risk-of-genetic-changes-11-fold-and-a-mothers-age-has-no-impact\/","title":{"rendered":"IVF increases a baby’s risk of genetic changes 11-FOLD – and a mother’s age has no impact"},"content":{"rendered":"

A mother’s age may not be to blame for the high risk of genetic disorders in IVF babies born to older women, a new mouse study suggests.<\/p>\n

Exposure to hormone therapy and embryo culture – when embryos are left to grow in a petri dish – appeared to have a powerful impact on the gene expression of mouse pups. <\/p>\n

The mother’s age, the scientists found, had no impact at all on the baby’s gene expression.<\/p>\n

The authors of the study, from the University of Pittsburgh, say their findings suggest something about the technology \u2013 not a woman’s age \u2013 is to blame for the high rate of babies born with disorders to older mothers who have undergone IVF.<\/p>\n

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\"For<\/div>\n

\"For<\/p>\n<\/div>\n

For decades, scientists have noticed a trend that IVF babies born to older mothers are more likely to be born prematurely, have a lower birth weight, and birth defects<\/p>\n<\/div>\n

‘Women of advanced maternal age might have one less thing to worry about,’ said lead author Audrey Kindsfather, a medical student researcher at Pittsburgh’s Magee-Womens Research Institute.<\/p>\n

‘We need clinical studies to back that up, but this is a promising animal model that clinical studies could be based on.’<\/p>\n

Since the first IVF baby was born in England in 1978, more than 1 million<\/a> US babies have been conceived using assisted reproductive technology. <\/p>\n

According to a recent analysis by Penn Medicine<\/a>, around 1 to 2 percent of US births every year are the result of IVF.<\/p>\n

The technology has allowed women to conceive well beyond the scope of their own biology, but clinics routinely warn mothers to be wary about leaving it too<\/span> late, even if they have the means to undergo multiple rounds. <\/p>\n

For decades, scientists have noticed a trend that IVF babies born to older mothers are more likely to be born prematurely, have a lower birth weight, and birth defects.  <\/p>\n

Research<\/a> earlier this year found that IVF technology itself does appear to leave a mark on several genes in all babies – and, hearteningly, that most of those changes appear to fade by adulthood.<\/p>\n

In older mothers, there is a higher risk of those marks affecting genes themselves (not just the gene expression), with a much higher risk of Down syndrome, for example. <\/p>\n

Kindsfather and colleagues wanted to investigate the root of all this: what impacts gene expression, is it due to age, technology, or a blend of the two?<\/p>\n

They studied two groups of mice of all ages. The control group conceiving naturally, and the other group underwent various fertility treatments – some receiving hormone treatment, some having their embryos grow in a petri dish, some undergoing both.  <\/p>\n

The scientists measures the number of epigenetic changes in each embryo at various stages. <\/p>\n

They found hormone therapy and time in the petri dish both affected gene transcription – and even more so when the two techniques were combined. <\/p>\n

Meanwhile, maternal age, on the other hand, had no impact on gene expression. <\/p>\n

‘It wasn’t what we were expecting,’ Dr Mellissa Mann, a professor of reproductive sciences at the university and a senior author on the paper, said. <\/p>\n

‘We know that as a woman ages, there are a lot of molecular changes happening to her eggs, so we thought that these changes could be leading to abnormal DNA methylation. We were quite surprised that it didn’t.’ <\/p>\n","protected":false},"excerpt":{"rendered":"

A mother’s age may not be to blame for the high risk of genetic disorders in IVF babies born to older women, a new mouse study suggests. Exposure to hormone therapy and embryo culture – when embryos are left to grow in a petri dish – appeared to have a powerful impact on the gene […]<\/p>\n","protected":false},"author":1,"featured_media":138067,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"rop_custom_images_group":[],"rop_custom_messages_group":[],"rop_publish_now":"initial","rop_publish_now_accounts":{"facebook_10221280388112155_325455220908133":""},"rop_publish_now_history":[],"rop_publish_now_status":"pending","footnotes":""},"categories":[23],"tags":[],"class_list":["post-138066","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-english-news"],"yoast_head":"\nIVF increases a baby's risk of genetic changes 11-FOLD - and a mother's age has no impact - Wardoon<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/wardoon.net\/so\/ivf-increases-a-babys-risk-of-genetic-changes-11-fold-and-a-mothers-age-has-no-impact\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"IVF increases a baby's risk of genetic changes 11-FOLD - and a mother's age has no impact - Wardoon\" \/>\n<meta property=\"og:description\" content=\"A mother’s age may not be to blame for the high risk of genetic disorders in IVF babies born to older women, a new mouse study suggests. 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